学习经历、社会兼职及获奖情况

徐金瑞，男，1975年生，教授，主要从事遗传学的教学和科研工作。主持在研国家自然科学基金项目2项，主持完成宁夏自然科学基金项目4项，宁夏高等学校科学技术研究项目2项，宁夏大学自然科学基金项目2项。参与完成国家自然科学基金项目2项，教育部科学技术研究重点项目1项。在国内外学术期刊发表论文40余篇，其中SCI收录14篇。宁夏生物分子检测学会理事，宁夏生物学会监事。承担本科生及研究生《遗传学》、《生物统计学》等课程的教学任务。先后荣获宁夏自然科学优秀学术论文二等奖1项、三等奖1项，获宁夏大学“第七届教学优秀奖”、宁夏大学“第二届青年教师教学基本功大赛三等奖”、宁夏大学“社会治安综合治理工作先进个人”、宁夏大学“优秀共产党员”、生命科学学院“教学评估先进个人”、生命科学学院“优秀共产党员”。

研究领域

病原菌与宿主互作机制研究

代表性研究成果

1. Jinrui Xu, Yanbin Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang. Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection. BMC Immunology (2020) 21:26. https://doi.org/10.1186/s12865-020-00356-x

2. Yi Yang, Yingfei Sun, Jinrui Xu, Kangda Bao, Meihui Luo, Xiaoming Liu, Yujiong Wang. Epithelial Cells Attenuate Toll-like Receptor-mediated Inflammatory Responses in Monocyte-derived Macrophage-like Cells to Mycobacterium tuberculosis by modulating PI3K/Akt/mTOR signaling pathway. Mediators of Inflammation, Volume 2018, Article ID 3685948, 19 pages（共同一作）

3. Han Cai, Bingying Liu, Tingting Yang, Yi Yang, Jinrui Xu, Zhiqing Wei, Guangcun Deng, Gang Ning, Junxia Li, Jing Wen, Wei Liu, Zhangli Ni, Yuzhen Ma, Meijia Zhang, Bo Zhou, Guoliang Xia, Hong Ouyang, Chao Wang, Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse, Biology Open (2018) 7, bio034678. doi:10.1242/bio.034678

4. Hao Yan, Jia Wen, Tuo Zhang, Wenying Zheng, Meina He, Kun Huang, Qirui Guo, Qian Chen, Yi Yang, Guangcun Deng, Jinrui Xu, Zhiqing Wei, Hua Zhang, Guoliang Xia , Chao Wang. Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice. cell death and disease

5. Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, Jinrui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, and Chao Wang. Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biology Open

6. Zhiqiang Li, Jianhua Chen, Ying Zhao, Yujiong Wang, Jinrui Xu, Jue Ji, Jingyi Shen,Weiping Zhang, Zuosong Chen, Qilin Sun, Lijuan Mao, Shulin Cheng, Bo Yang, Dongtao Zhang, Yufeng Xu, Yingying Zhao, Danping Liu, Yinhuan Shen, Weijie Zhang, Changgui Li, Jiawei Shen, Yongyong Shi. Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea. NATURE COMMUNICATIONS, 2017,8:14900. doi:10.1038/ncomms14900

7. Yi Yang, Jinrui Xu, Yujiong Wang, Xiaoming Liu*. Polymorphic association of TCF7L2 gene with the susceptibility to type 2 diabetes mellitus in a Chinese Hui population. Genetics and Molecular Research, 2015, 14 (3): 10064-10071.

8. Jinrui Xu, Yi Yang, Xiaoming Liu and Yujiong Wang*. Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations. Genetics and Molecular Research, 2014, 13(4): 9588-9598.

9. Yi Yang, Jinrui Xu, Xiaoming Liu, Jin Zhou, Bo Yang, Min Li and Yujiong Wang*, Polymorphism of +2836 G＞A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population，Genetic and Molecular Research, 2014, 13(1): 1212-1219.

10. Bo Yang, Jinru Xu, Xiaoming Liu, Yi Yang , Xiaofei Na, Min Li, Yujiong Wang*, Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of eNOS gene associated with the susceptibility to essential hypertension in the Chinese Hui ethnic population. Genetics and Molecular Research, 2013, 12 (3): 3821-3829 .(共同一作)

11. J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun, Y.J. Wang*. Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population. Genetics and Molecular Research，2012, 11(1): 61-69.

12. J. Xu, Y. Yang, X. Liu, Y. Wang. Genetic variation and significant association of polymorphism rs7700944 G>A of TIM-4 gene with rheumatoid arthritis susceptibility in Chinese Han and Hui populations. International Journal of Immunogenetics, 2012，39(5):409-413.

13. J. Xu, Y. Yang, X. Liu, Y. Wang*. The -1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui Population. International Journal of Immunogenetics, 2011, 38 (6): 513-518.

14. Jinrui Xu, Hongsong Fan, Yanfei Tan, and Xingdong Zhang, Gene Expressions Induced by Calcium Phosphate Ceramics after Implantation into the Muscle of rat, Materials Science Forum 2005, 475: 2363-2366